Procarbazine hydrochloride (Matulane)
procarbazine hydrochloride
CAS: 366-70-1
Molecular Formula: C12H20ClN3O
Procarbazine hydrochloride (Matulane) - Names and Identifiers
| Name | procarbazine hydrochloride |
| Synonyms | ibz matulane NSC-77213 HCl Procarbazine HCL procarbazine hydrochloride ibenzmethyzinhydrochloride Procarbazine hydrochloride (Matulane) 4-[(2-methylhydrazinyl)methyl]-N-(propan-2-yl)benzamide N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride |
| CAS | 366-70-1 |
| EINECS | 206-678-6 |
| InChI | InChI=1/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H |
Procarbazine hydrochloride (Matulane) - Physico-chemical Properties
| Molecular Formula | C12H20ClN3O |
| Molar Mass | 257.76 |
| Density | 8.3 g/cm3 |
| Melting Point | 223°C |
| Boling Point | 384.6°C at 760 mmHg |
| Flash Point | 148.9°C |
| Water Solubility | >=10 g/100 mL at 21.5 ºC |
| Solubility | DMSO: ≥18mg/mL |
| Vapor Presure | 4.05E-06mmHg at 25°C |
| Appearance | powder |
| Color | white to tan |
| Merck | 14,7758 |
| Storage Condition | Inert atmosphere,2-8°C |
| MDL | MFCD00072082 |
| Use | Procarbazine HCl is a Procarbazine hydrochloride form, a polyfunctional alkylating agent compound and an antitumor agent. |
| In vitro study | Procarbazine and copper (II) induced ACG-3-labile and formamidopyrimidine-DNA glycosylase-sensitive lesions on the 5 '-pipeline' sequence, hot-spot complementation of the p53 gene and the 5'-TG-3 sequence. Procarbazine causes DNA damage through non-enzymatic formation of the Cu(I)-hydroperoxo complex and methyl radicals. Procarbazine has a strong cleft-inducing effect in hematopoietic cells and is a substance that induces mutations in the organism in a variety of organs treated at high doses. |
| In vivo study | Procarbazine caused a significant decrease in testicular epididymal weight, a significant decrease in haploid cells and a significant decrease in spermatogenic block, demonstrating changes in golden hamsters. In rats, Procarbazine dose-dependently enhanced the effect of MAO A in brown adipose tissue, and the increase was more obvious after the addition of methylhydrazine, and the activity increased by 350. Procarbazine or methylhydrazine decreased the metabolism of this amine to a similar extent as in isolated vascular homogenates. In rodents and monkeys, Procarbazine is mutagenic, cleavogenic and teratogenic in a wide range of varying complexity and broad-spectrum carcinogens, causing tumors of the hematopoietic system, mammary gland, lung and nervous system. Procarbazine undergoes a series of metabolic changes in the body, leading to the production of chemically reactive substances, including methylating agents and free radicals. |
Procarbazine hydrochloride (Matulane) - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R45 - May cause cancer R61 - May cause harm to the unborn child R22 - Harmful if swallowed R68 - Possible risk of irreversible effects |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
| RTECS | XS4725000 |
| HS Code | 2928002500 |
| Toxicity | LD50 orally in rats: 785 ±34 mg/kg (Goldenthal) |
Procarbazine hydrochloride (Matulane) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.88 ml | 19.398 ml | 38.796 ml |
| 5 mM | 0.776 ml | 3.88 ml | 7.759 ml |
| 10 mM | 0.388 ml | 1.94 ml | 3.88 ml |
| 5 mM | 0.078 ml | 0.388 ml | 0.776 ml |
Last Update：2024-01-02 23:10:35
Procarbazine hydrochloride (Matulane) - Reference Information
| (IARC) carcinogen classification | 2A (Vol. 26, Sup 7) 1987 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Biological activity | Procarbazine HCl (NSC-77213) is a Procarbazine hydrochloride form, a multifunctional alkylating agent compound, and an anti-tumor agent. |
Last Update：2024-04-09 02:00:08
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